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Side Effects of Oral Appliance Therapy — What Patients Should Know

📅 March 24, 2026 · ⏱ 7 min read · SkipTheCPAP Editorial Team

Are There Side Effects to Wearing a Sleep Apnea Mouthguard?

Oral appliance therapy is one of the safest treatments available for obstructive sleep apnea. Most patients tolerate their device very well — especially compared to CPAP, which has a 30–50% abandonment rate largely due to side effects and discomfort. That said, some patients experience side effects, most of which are temporary or easily managed by your dental sleep specialist.

Common Short-Term Side Effects

During the first few weeks of wearing a mandibular advancement device, many patients experience:

Long-Term Side Effects to Monitor

With years of nightly use, a small percentage of patients experience more lasting changes:

How Specialists Minimize Side Effects

A key advantage of working with a qualified dental sleep medicine specialist is that they actively monitor for side effects and make adjustments to prevent problems. This includes:

Who Should Be Cautious

Oral appliance therapy may not be suitable for patients with active TMJ disorder, insufficient teeth to support the device, certain types of dental work, or severe gum disease. A thorough examination by a dental sleep specialist will identify any contraindications before treatment begins.

The Bottom Line on Side Effects

The vast majority of patients tolerate oral appliance therapy very well and find the minor initial adjustment period worth the long-term benefits of treating their sleep apnea without a CPAP machine. The key is working with an experienced dental sleep medicine specialist who knows how to fit, adjust, and monitor the device properly. Find a qualified specialist near you at SkipTheCPAP.com.

📋 Medical Disclaimer: This article is for informational and educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult a qualified physician or licensed dental sleep medicine specialist before making any healthcare decisions. Individual results may vary.
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